All adjustment should be done with a hand screwdriver.
To release the draw front, turn screw half turn (anti-clockwise one side and clockwise the other). This will make fitting the handles a lot easier.
The left to right adjustment needs to be done on both sides of the draw (again, one side did anti-clockwise and the other clockwise)
The vertical adjustment screw is on a cam, so it will keep going round/up and down.